藥物交互作用
Atenolol-chlorthalidone + Vitamin d
嚴重程度: 中度
Atenolol-chlorthalidone and Vitamin d: moderate interaction.
最後更新
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摘要
Thiazide-type diuretics such as chlorthalidone reduce urinary calcium excretion. Combined with vitamin D, which enhances calcium absorption, this can cause hypercalcemia, particularly with high doses or in renal impairment.
用白話說明這項交互作用的意義
Atenolol-chlorthalidone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
為什麼會發生
Reduced renal calcium excretion from the thiazide plus increased intestinal calcium absorption from vitamin D.
處置方式
Monitor serum calcium and renal function periodically, especially when doses are high or calcium supplements are also used. Reduce the vitamin D or calcium dose if hypercalcemia develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Atenolol-chlorthalidone 的其他交互作用
Vitamin d 的其他交互作用
常見問題
Can I take Atenolol-chlorthalidone with Vitamin d?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics such as chlorthalidone reduce urinary calcium excretion. Combined with vitamin D, which enhances calcium absorption, this can cause hypercalcemia, particularly with high doses or in renal impairment.
How serious is the interaction between Atenolol-chlorthalidone and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, especially when doses are high or calcium supplements are also used. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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