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Amlodipine-hydrochlorothiazide-valsartan + Vitamin d

嚴重程度: 中度

Amlodipine-hydrochlorothiazide-valsartan and Vitamin d: moderate interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Thiazide diuretics reduce renal calcium excretion, and vitamin D increases intestinal calcium absorption. Together they may cause hypercalcemia, particularly with high-dose vitamin D or in patients with renal impairment.

用白話說明這項交互作用的意義

Amlodipine-hydrochlorothiazide-valsartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.

證據等級: High

為什麼會發生

Reduced urinary calcium excretion by hydrochlorothiazide combined with increased calcium absorption from vitamin D.

處置方式

Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or review the thiazide if hypercalcemia occurs.

可向藥師詢問的問題

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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常見問題

Can I take Amlodipine-hydrochlorothiazide-valsartan with Vitamin d?

MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce renal calcium excretion, and vitamin D increases intestinal calcium absorption. Together they may cause hypercalcemia, particularly with high-dose vitamin D or in patients with renal impairment.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Vitamin d?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D dose or review the thiazide if hypercalcemia occurs.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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