藥物交互作用
Atidarsagene autotemcel + Emtricitabine
嚴重程度: 嚴重
Atidarsagene autotemcel and Emtricitabine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Antiretrovirals may impair lentiviral transduction of the patient's collected hematopoietic cells and interfere with manufacture of the gene therapy. This could reduce its effectiveness.
用白話說明這項交互作用的意義
Atidarsagene autotemcel and Emtricitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Emtricitabine belongs to Anti Virals.
為什麼會發生
Reverse transcriptase inhibitors can interfere with lentiviral vector transduction during cell manufacturing.
處置方式
Stop emtricitabine-containing therapy at least 1 month before mobilization and keep it off through apheresis. Arrange alternative HIV management with a specialist.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Emtricitabine 的其他交互作用
Atidarsagene autotemcel 的其他交互作用
常見問題
Can I take Atidarsagene autotemcel with Emtricitabine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Emtricitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals may impair lentiviral transduction of the patient's collected hematopoietic cells and interfere with manufacture of the gene therapy. This could reduce its effectiveness.
How serious is the interaction between Atidarsagene autotemcel and Emtricitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop emtricitabine-containing therapy at least 1 month before mobilization and keep it off through apheresis. Arrange alternative HIV management with a specialist.
What other medicines interact with Emtricitabine?
MediHelp also lists interactions of Emtricitabine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Emtricitabine page.
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