藥物交互作用
Atidarsagene autotemcel + Dolutegravir
嚴重程度: 嚴重
Atidarsagene autotemcel and Dolutegravir: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Antiretroviral drugs can interfere with manufacture of this lentiviral gene therapy by inhibiting transduction. Dolutegravir, an integrase inhibitor, may compromise product quality if present at apheresis.
用白話說明這項交互作用的意義
Atidarsagene autotemcel and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Dolutegravir belongs to Anti Virals.
為什麼會發生
Antiretroviral activity inhibits lentiviral vector transduction of harvested cells.
處置方式
Stop dolutegravir at least one month before mobilization, allowing for elimination, and keep it off through apheresis. Arrange interim HIV management with specialists.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dolutegravir 的其他交互作用
Atidarsagene autotemcel 的其他交互作用
常見問題
Can I take Atidarsagene autotemcel with Dolutegravir?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretroviral drugs can interfere with manufacture of this lentiviral gene therapy by inhibiting transduction. Dolutegravir, an integrase inhibitor, may compromise product quality if present at apheresis.
How serious is the interaction between Atidarsagene autotemcel and Dolutegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop dolutegravir at least one month before mobilization, allowing for elimination, and keep it off through apheresis. Arrange interim HIV management with specialists.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Betibeglogene autotemcel. The full list is on the Dolutegravir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
