藥物交互作用
Atomoxetine + Dacomitinib
嚴重程度: 嚴重
Atomoxetine and Dacomitinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Dacomitinib strongly inhibits CYP2D6, the main enzyme that clears atomoxetine. Atomoxetine exposure may rise to levels like those in CYP2D6 poor metabolisers, increasing adverse effects such as hypertension, tachycardia and insomnia.
用白話說明這項交互作用的意義
Atomoxetine and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atomoxetine belongs to Central Nervous System; Dacomitinib belongs to Oncology.
為什麼會發生
Dacomitinib inhibits CYP2D6, reducing atomoxetine metabolism.
處置方式
Start atomoxetine at the lower dose and increase only if tolerated, or choose an alternative. Monitor heart rate and blood pressure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atomoxetine 的其他交互作用
Dacomitinib 的其他交互作用
常見問題
Can I take Atomoxetine with Dacomitinib?
MediHelp rates the interaction as major. Atomoxetine and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib strongly inhibits CYP2D6, the main enzyme that clears atomoxetine. Atomoxetine exposure may rise to levels like those in CYP2D6 poor metabolisers, increasing adverse effects such as hypertension, tachycardia and insomnia.
How serious is the interaction between Atomoxetine and Dacomitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start atomoxetine at the lower dose and increase only if tolerated, or choose an alternative. Monitor heart rate and blood pressure.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
