藥物交互作用
Amitriptyline + Dacomitinib
嚴重程度: 嚴重
Amitriptyline and Dacomitinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise amitriptyline concentrations. This may increase anticholinergic effects, sedation, QT prolongation and arrhythmia risk.
用白話說明這項交互作用的意義
Amitriptyline and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Dacomitinib belongs to Oncology.
為什麼會發生
Dacomitinib inhibits CYP2D6, reducing the metabolism of amitriptyline and its active metabolite.
處置方式
Avoid if possible or reduce the amitriptyline dose and monitor for toxicity. Check an ECG and consider tricyclic levels in higher-risk patients.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amitriptyline 的其他交互作用
Dacomitinib 的其他交互作用
常見問題
Can I take Amitriptyline with Dacomitinib?
MediHelp rates the interaction as major. Amitriptyline and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise amitriptyline concentrations. This may increase anticholinergic effects, sedation, QT prolongation and arrhythmia risk.
How serious is the interaction between Amitriptyline and Dacomitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or reduce the amitriptyline dose and monitor for toxicity. Check an ECG and consider tricyclic levels in higher-risk patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
