藥物交互作用
Disopyramide + Ketoconazole
嚴重程度: 禁忌併用
Disopyramide and Ketoconazole: contraindicated interaction.
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摘要
Ketoconazole increases disopyramide levels and both drugs prolong the QT interval. This raises the risk of torsades de pointes and other ventricular arrhythmias.
用白話說明這項交互作用的意義
Disopyramide and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
為什麼會發生
CYP3A4 inhibition by ketoconazole raises disopyramide exposure, combined with additive QT prolongation.
處置方式
Avoid the combination. Use an antifungal with less QT and CYP3A4 effect, or an alternative antiarrhythmic.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ketoconazole 的其他交互作用
Disopyramide 的其他交互作用
常見問題
Can I take Disopyramide with Ketoconazole?
MediHelp rates the interaction as contraindicated. Disopyramide and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole increases disopyramide levels and both drugs prolong the QT interval. This raises the risk of torsades de pointes and other ventricular arrhythmias.
How serious is the interaction between Disopyramide and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use an antifungal with less QT and CYP3A4 effect, or an alternative antiarrhythmic.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
