藥物交互作用
Axicabtagene ciloleucel + Chlorambucil
嚴重程度: 嚴重
Axicabtagene ciloleucel and Chlorambucil: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Chlorambucil is myelosuppressive and immunosuppressive, and exposure around CAR-T infusion may add to infection risk and could impair CAR-T cell expansion. It is not part of the usual lymphodepletion regimen.
用白話說明這項交互作用的意義
Axicabtagene ciloleucel and Chlorambucil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Chlorambucil belongs to Oncology.
為什麼會發生
Additive immunosuppression and marrow suppression that may impair CAR-T cell expansion and function.
處置方式
Stop chlorambucil well before leukapheresis and lymphodepletion as directed by the CAR-T protocol, and avoid it afterwards unless essential. Monitor for infection and cytopenias.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlorambucil 的其他交互作用
Axicabtagene ciloleucel 的其他交互作用
常見問題
Can I take Axicabtagene ciloleucel with Chlorambucil?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Chlorambucil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorambucil is myelosuppressive and immunosuppressive, and exposure around CAR-T infusion may add to infection risk and could impair CAR-T cell expansion. It is not part of the usual lymphodepletion regimen.
How serious is the interaction between Axicabtagene ciloleucel and Chlorambucil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop chlorambucil well before leukapheresis and lymphodepletion as directed by the CAR-T protocol, and avoid it afterwards unless essential. Monitor for infection and cytopenias.
What other medicines interact with Chlorambucil?
MediHelp also lists interactions of Chlorambucil with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Chlorambucil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
