藥物交互作用
Azathioprine + Ciltacabtagene autoleucel
嚴重程度: 嚴重
Azathioprine and Ciltacabtagene autoleucel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. It also increases the risk of infection during the cytopenic period after CAR-T therapy.
用白話說明這項交互作用的意義
Azathioprine and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Ciltacabtagene autoleucel belongs to Miscellaneous.
為什麼會發生
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
處置方式
Discontinue azathioprine before leukapheresis and infusion as directed by the treating center. Monitor for infection if it must continue.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Azathioprine 的其他交互作用
Ciltacabtagene autoleucel 的其他交互作用
常見問題
Can I take Azathioprine with Ciltacabtagene autoleucel?
MediHelp rates the interaction as major. Azathioprine and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. It also increases the risk of infection during the cytopenic period after CAR-T therapy.
How serious is the interaction between Azathioprine and Ciltacabtagene autoleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue azathioprine before leukapheresis and infusion as directed by the treating center. Monitor for infection if it must continue.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
