藥物交互作用
Azelastine + Calcium / magnesium / potassium / sodium oxybates
嚴重程度: 嚴重
Azelastine and Calcium / magnesium / potassium / sodium oxybates: major interaction.
最後更新
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摘要
Oxybates cause profound CNS and respiratory depression, and other sedating agents add to this effect. Azelastine, particularly the nasal spray, can cause somnolence and may worsen sedation, impaired alertness and breathing depression when used with oxybates.
用白話說明這項交互作用的意義
Azelastine and Calcium / magnesium / potassium / sodium oxybates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive central nervous system depressant effects.
處置方式
Avoid combining where possible and choose a non-sedating alternative such as an intranasal corticosteroid. If used together, monitor for excess sedation and respiratory depression and consider reducing the oxybate dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Azelastine 的其他交互作用
常見問題
Can I take Azelastine with Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates the interaction as major. Azelastine and Calcium / magnesium / potassium / sodium oxybates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates cause profound CNS and respiratory depression, and other sedating agents add to this effect. Azelastine, particularly the nasal spray, can cause somnolence and may worsen sedation, impaired alertness and breathing depression when used with oxybates.
How serious is the interaction between Azelastine and Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose a non-sedating alternative such as an intranasal corticosteroid. If used together, monitor for excess sedation and respiratory depression and consider reducing the oxybate dose.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Methadone, Sodium oxybate, Alfentanil. The full list is on the Azelastine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
