藥物交互作用
Amobarbital + Azelastine
嚴重程度: 中度
Amobarbital and Azelastine: moderate interaction.
最後更新
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摘要
Amobarbital is a barbiturate with marked CNS depressant effects, and azelastine adds sedative H1-antagonist activity. The combination may deepen sedation and impair alertness or respiration.
用白話說明這項交互作用的意義
Amobarbital and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Azelastine belongs to Respiratory.
為什麼會發生
Additive CNS depression through H1-receptor blockade and barbiturate potentiation of GABA-A receptor activity.
處置方式
Monitor for excessive sedation and respiratory depression, especially at higher barbiturate doses. Consider a non-sedating alternative to azelastine where appropriate.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Azelastine 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Azelastine?
MediHelp rates the interaction as moderate. Amobarbital and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is a barbiturate with marked CNS depressant effects, and azelastine adds sedative H1-antagonist activity. The combination may deepen sedation and impair alertness or respiration.
How serious is the interaction between Amobarbital and Azelastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, especially at higher barbiturate doses. Consider a non-sedating alternative to azelastine where appropriate.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
