藥物交互作用
Azelastine + Methadone
嚴重程度: 嚴重
Azelastine and Methadone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Azelastine may intensify methadone-related sedation and respiratory depression. Methadone has a long, variable half-life, so excess CNS depression can emerge and persist.
用白話說明這項交互作用的意義
Azelastine and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azelastine belongs to Respiratory; Methadone belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression from H1-antagonist sedation and mu-opioid agonism.
處置方式
Monitor sedation and respiratory status, particularly at initiation and dose changes. Avoid other CNS depressants and consider a non-sedating antihistamine alternative.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Azelastine 的其他交互作用
Methadone 的其他交互作用
常見問題
Can I take Azelastine with Methadone?
MediHelp rates the interaction as major. Azelastine and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azelastine may intensify methadone-related sedation and respiratory depression. Methadone has a long, variable half-life, so excess CNS depression can emerge and persist.
How serious is the interaction between Azelastine and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, particularly at initiation and dose changes. Avoid other CNS depressants and consider a non-sedating antihistamine alternative.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
