藥物交互作用
Bazedoxifene-conjugated estrogens + Dalteparin
嚴重程度: 嚴重
Bazedoxifene-conjugated estrogens and Dalteparin: major interaction.
最後更新
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摘要
Conjugated estrogens and bazedoxifene both raise the risk of venous thromboembolism, which is exactly what dalteparin is given to prevent or treat. The prothrombotic estrogen effect may undermine anticoagulation, and the combination is generally inappropriate in active or prior VTE.
用白話說明這項交互作用的意義
Bazedoxifene-conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Dalteparin belongs to Cardiovascular.
為什麼會發生
Estrogen and SERM-related prothrombotic changes (increased clotting factors, reduced antithrombin) counteract anticoagulant effect
處置方式
Avoid the estrogen/bazedoxifene combination in patients needing therapeutic anticoagulation for VTE; if prophylactic anticoagulation overlaps, reassess the need for hormone therapy.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bazedoxifene-conjugated estrogens 的其他交互作用
- Anastrozole + Bazedoxifene-conjugated estrogens 禁忌併用
- Bazedoxifene-conjugated estrogens + Ospemifene 禁忌併用
- Antithrombin alfa + Bazedoxifene-conjugated estrogens 嚴重
- Antithrombin iii + Bazedoxifene-conjugated estrogens 嚴重
- Bazedoxifene-conjugated estrogens + Bemiparin 嚴重
- Bazedoxifene-conjugated estrogens + Carbamazepine 嚴重
Dalteparin 的其他交互作用
常見問題
Can I take Bazedoxifene-conjugated estrogens with Dalteparin?
MediHelp rates the interaction as major. Bazedoxifene-conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conjugated estrogens and bazedoxifene both raise the risk of venous thromboembolism, which is exactly what dalteparin is given to prevent or treat. The prothrombotic estrogen effect may undermine anticoagulation, and the combination is generally inappropriate in active or prior VTE.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the estrogen/bazedoxifene combination in patients needing therapeutic anticoagulation for VTE; if prophylactic anticoagulation overlaps, reassess the need for hormone therapy.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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