藥物交互作用
Belimumab + Human papillomavirus vaccine
嚴重程度: 中度
Belimumab and Human papillomavirus vaccine: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Belimumab suppresses B-cell survival and may blunt the antibody response to HPV vaccination. Protection may therefore be lower than expected, although the vaccine is non-live and not unsafe.
用白話說明這項交互作用的意義
Belimumab and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belimumab belongs to Miscellaneous; Human papillomavirus vaccine belongs to Miscellaneous.
為什麼會發生
Pharmacodynamic antagonism: belimumab inhibits BLyS and reduces B-cell mediated humoral immune responses.
處置方式
Where possible, complete HPV vaccination before starting belimumab. If given during therapy, do not withhold the vaccine, and consider checking response or revaccinating when immunosuppression is reduced.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Human papillomavirus vaccine 的其他交互作用
- Antithymocyte globulin equine + Human papillomavirus vaccine 中度
- Antithymocyte globulin rabbit + Human papillomavirus vaccine 中度
- Atidarsagene autotemcel + Human papillomavirus vaccine 中度
- Cortisone + Human papillomavirus vaccine 中度
- Cyclosporine + Human papillomavirus vaccine 中度
- Elivaldogene autotemcel + Human papillomavirus vaccine 中度
Belimumab 的其他交互作用
常見問題
Can I take Belimumab with Human papillomavirus vaccine?
MediHelp rates the interaction as moderate. Belimumab and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belimumab suppresses B-cell survival and may blunt the antibody response to HPV vaccination. Protection may therefore be lower than expected, although the vaccine is non-live and not unsafe.
How serious is the interaction between Belimumab and Human papillomavirus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, complete HPV vaccination before starting belimumab. If given during therapy, do not withhold the vaccine, and consider checking response or revaccinating when immunosuppression is reduced.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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