Drug interactions
Belimumab + Human papillomavirus vaccine
Severity: Moderate
Belimumab and Human papillomavirus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belimumab suppresses B-cell survival and may blunt the antibody response to HPV vaccination. Protection may therefore be lower than expected, although the vaccine is non-live and not unsafe.
What this interaction means in plain words
Belimumab and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belimumab belongs to Miscellaneous; Human papillomavirus vaccine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism: belimumab inhibits BLyS and reduces B-cell mediated humoral immune responses.
What to do
Where possible, complete HPV vaccination before starting belimumab. If given during therapy, do not withhold the vaccine, and consider checking response or revaccinating when immunosuppression is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
- Elivaldogene autotemcel + Human papillomavirus vaccine Moderate
Other interactions of Belimumab
- Belimumab + Measles mumps and rubella vaccine Major
- Abatacept + Belimumab Moderate
- Adalimumab + Belimumab Moderate
- Anakinra + Belimumab Moderate
- Anti-thymocyte + Belimumab Moderate
- Belimumab + Denosumab Moderate
Frequently asked questions
Can I take Belimumab with Human papillomavirus vaccine?
MediHelp rates the interaction as moderate. Belimumab and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belimumab suppresses B-cell survival and may blunt the antibody response to HPV vaccination. Protection may therefore be lower than expected, although the vaccine is non-live and not unsafe.
How serious is the interaction between Belimumab and Human papillomavirus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, complete HPV vaccination before starting belimumab. If given during therapy, do not withhold the vaccine, and consider checking response or revaccinating when immunosuppression is reduced.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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