藥物交互作用
Belladonna and opium + Butorphanol
嚴重程度: 嚴重
Belladonna and opium and Butorphanol: major interaction.
最後更新
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摘要
Opium in this combination is a full mu agonist, and butorphanol can add to its sedation and respiratory depression. In opioid-tolerant patients, butorphanol's partial antagonist activity may blunt analgesia or provoke withdrawal.
用白話說明這項交互作用的意義
Belladonna and opium and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive opioid CNS depression combined with partial mu antagonism by butorphanol at receptors occupied by morphine from opium.
處置方式
Avoid concurrent use and choose a single opioid regimen. If unavoidable, monitor sedation, respiratory status and withdrawal symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Butorphanol 的其他交互作用
常見問題
Can I take Belladonna and opium with Butorphanol?
MediHelp rates the interaction as major. Belladonna and opium and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium in this combination is a full mu agonist, and butorphanol can add to its sedation and respiratory depression. In opioid-tolerant patients, butorphanol's partial antagonist activity may blunt analgesia or provoke withdrawal.
How serious is the interaction between Belladonna and opium and Butorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single opioid regimen. If unavoidable, monitor sedation, respiratory status and withdrawal symptoms.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
