藥物交互作用
Amobarbital + Butorphanol
嚴重程度: 嚴重
Amobarbital and Butorphanol: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Barbiturates and opioids together can cause deep sedation, respiratory depression, coma and death. The risk is greatest at higher doses and in frail or opioid-naive patients.
用白話說明這項交互作用的意義
Amobarbital and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Butorphanol belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression via opioid receptors and enhanced GABA-A activity.
處置方式
Avoid if possible; if both are required, use reduced doses with close monitoring of respiratory rate and level of consciousness.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Butorphanol 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Butorphanol?
MediHelp rates the interaction as major. Amobarbital and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and opioids together can cause deep sedation, respiratory depression, coma and death. The risk is greatest at higher doses and in frail or opioid-naive patients.
How serious is the interaction between Amobarbital and Butorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are required, use reduced doses with close monitoring of respiratory rate and level of consciousness.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
