藥物交互作用
Benazepril + Empagliflozin-linagliptin
嚴重程度: 中度
Benazepril and Empagliflozin-linagliptin: moderate interaction.
最後更新
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摘要
DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
用白話說明這項交互作用的意義
Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Empagliflozin-linagliptin belongs to Endocrine.
為什麼會發生
Additive reduction in bradykinin and substance P degradation through ACE and DPP-4 inhibition.
處置方式
Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Empagliflozin-linagliptin 的其他交互作用
Benazepril 的其他交互作用
常見問題
Can I take Benazepril with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
How serious is the interaction between Benazepril and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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