藥物交互作用
Empagliflozin-linagliptin + Fosphenytoin
嚴重程度: 嚴重
Empagliflozin-linagliptin and Fosphenytoin: major interaction.
最後更新
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摘要
Fosphenytoin is converted to phenytoin, a strong inducer of CYP3A4 and P-glycoprotein, which can substantially lower linagliptin exposure. Loss of linagliptin effect may lead to worsened glycemic control.
用白話說明這項交互作用的意義
Empagliflozin-linagliptin and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Empagliflozin-linagliptin belongs to Endocrine; Fosphenytoin belongs to Central Nervous System.
為什麼會發生
Phenytoin induces CYP3A4 and P-glycoprotein, increasing linagliptin clearance.
處置方式
Linagliptin labeling advises an alternative to strong inducers; use a different antidiabetic agent where possible, otherwise monitor glucose and HbA1c closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Empagliflozin-linagliptin 的其他交互作用
Fosphenytoin 的其他交互作用
常見問題
Can I take Empagliflozin-linagliptin with Fosphenytoin?
MediHelp rates the interaction as major. Empagliflozin-linagliptin and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosphenytoin is converted to phenytoin, a strong inducer of CYP3A4 and P-glycoprotein, which can substantially lower linagliptin exposure. Loss of linagliptin effect may lead to worsened glycemic control.
How serious is the interaction between Empagliflozin-linagliptin and Fosphenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Linagliptin labeling advises an alternative to strong inducers; use a different antidiabetic agent where possible, otherwise monitor glucose and HbA1c closely.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Rifampin, Rifapentine, Amiloride. The full list is on the Empagliflozin-linagliptin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
