藥物交互作用
Benzhydrocodone / acetaminophen + Chloramphenicol
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Chloramphenicol: major interaction.
最後更新
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摘要
Benzhydrocodone is a prodrug of hydrocodone, which is metabolized by CYP3A4. Chloramphenicol may inhibit this pathway, raising hydrocodone levels and risking sedation and potentially fatal respiratory depression.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of hydrocodone, increasing its plasma concentrations.
處置方式
Avoid if possible or use a lower opioid dose and monitor closely for sedation and respiratory depression. Reassess the dose if chloramphenicol is stopped, since opioid levels will fall.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chloramphenicol 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Chloramphenicol?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is a prodrug of hydrocodone, which is metabolized by CYP3A4. Chloramphenicol may inhibit this pathway, raising hydrocodone levels and risking sedation and potentially fatal respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Chloramphenicol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or use a lower opioid dose and monitor closely for sedation and respiratory depression. Reassess the dose if chloramphenicol is stopped, since opioid levels will fall.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
