藥物交互作用
Chloramphenicol + Cobimetinib
嚴重程度: 嚴重
Chloramphenicol and Cobimetinib: major interaction.
最後更新
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摘要
Chloramphenicol can inhibit CYP3A4 and may raise cobimetinib concentrations. Higher exposure may increase adverse effects such as hemorrhage, rhabdomyolysis, serous retinopathy, liver injury and cardiomyopathy.
用白話說明這項交互作用的意義
Chloramphenicol and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Cobimetinib belongs to Oncology.
為什麼會發生
Chloramphenicol inhibits CYP3A4-mediated metabolism of cobimetinib, a CYP3A substrate.
處置方式
Avoid chloramphenicol in patients on cobimetinib and choose an antibiotic without CYP3A inhibition. If unavoidable, reduce the cobimetinib dose per labeling guidance for CYP3A inhibitors and monitor closely for toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chloramphenicol 的其他交互作用
Cobimetinib 的其他交互作用
常見問題
Can I take Chloramphenicol with Cobimetinib?
MediHelp rates the interaction as major. Chloramphenicol and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol can inhibit CYP3A4 and may raise cobimetinib concentrations. Higher exposure may increase adverse effects such as hemorrhage, rhabdomyolysis, serous retinopathy, liver injury and cardiomyopathy.
How serious is the interaction between Chloramphenicol and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chloramphenicol in patients on cobimetinib and choose an antibiotic without CYP3A inhibition. If unavoidable, reduce the cobimetinib dose per labeling guidance for CYP3A inhibitors and monitor closely for toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
