藥物交互作用
Bivalirudin + Piperacillin-tazobactam
嚴重程度: 中度
Bivalirudin and Piperacillin-tazobactam: moderate interaction.
最後更新
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摘要
Piperacillin can impair platelet function and occasionally cause bleeding, which may add to the anticoagulant effect of bivalirudin. Clinical significance is usually modest. Risk is higher in renal impairment, where both drugs accumulate.
用白話說明這項交互作用的意義
Bivalirudin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive bleeding risk from direct thrombin inhibition plus penicillin-induced platelet dysfunction.
處置方式
Monitor for bleeding and ACT or aPTT during bivalirudin therapy. Adjust bivalirudin dose for renal function.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Piperacillin-tazobactam 的其他交互作用
常見問題
Can I take Bivalirudin with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Bivalirudin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet function and occasionally cause bleeding, which may add to the anticoagulant effect of bivalirudin. Clinical significance is usually modest. Risk is higher in renal impairment, where both drugs accumulate.
How serious is the interaction between Bivalirudin and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and ACT or aPTT during bivalirudin therapy. Adjust bivalirudin dose for renal function.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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