藥物交互作用
Brentuximab + Idelalisib
嚴重程度: 嚴重
Brentuximab and Idelalisib: major interaction.
最後更新
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摘要
Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
用白話說明這項交互作用的意義
Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab belongs to Oncology; Idelalisib belongs to Oncology.
為什麼會發生
Strong CYP3A inhibition by idelalisib reduces MMAE metabolism and increases exposure.
處置方式
Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Brentuximab 的其他交互作用
Idelalisib 的其他交互作用
常見問題
Can I take Brentuximab with Idelalisib?
MediHelp rates the interaction as major. Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
How serious is the interaction between Brentuximab and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
