藥物交互作用
Brentuximab + Etrasimod
嚴重程度: 嚴重
Brentuximab and Etrasimod: major interaction.
最後更新
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摘要
Brentuximab vedotin is cytotoxic and can cause neutropenia and serious infections, while etrasimod reduces circulating lymphocytes. Together they may add to infection risk, and etrasimod labeling advises against combining it with antineoplastic therapies. Effects of etrasimod persist for weeks after discontinuation.
用白話說明這項交互作用的意義
Brentuximab and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
為什麼會發生
Additive immunosuppression from myelosuppression due to the brentuximab vedotin payload and lymphocyte sequestration due to etrasimod.
處置方式
Avoid combining where an alternative exists, including for weeks after stopping etrasimod. If unavoidable, monitor blood counts and watch for infection.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Brentuximab 的其他交互作用
Etrasimod 的其他交互作用
常見問題
Can I take Brentuximab with Etrasimod?
MediHelp rates the interaction as major. Brentuximab and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brentuximab vedotin is cytotoxic and can cause neutropenia and serious infections, while etrasimod reduces circulating lymphocytes. Together they may add to infection risk, and etrasimod labeling advises against combining it with antineoplastic therapies. Effects of etrasimod persist for weeks after discontinuation.
How serious is the interaction between Brentuximab and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists, including for weeks after stopping etrasimod. If unavoidable, monitor blood counts and watch for infection.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Idelalisib. The full list is on the Brentuximab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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