藥品參考
Brentuximab
Brentuximab is a medicine in the class oncology. It is used for hodgkin lymphoma.
- 藥物類別: Oncology
- 用途: hodgkin lymphoma
最後更新
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重點資訊
- 藥物類別
- Oncology
- 常見劑型
- 輸注液
- 常見規格
- 50 mg
- 已知交互作用
- 72 (禁忌併用: 1 · 嚴重: 7 · 中度: 47 · 輕微: 17)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
CD30-directed antibody-drug conjugate (ADC) consisting of chimeric IgG1 antibody cAC10, specific for human CD30 and the microtubule disrupting agent, monomethyl auristatin E (MMAE, or vedotin). Conjugate binds to cell expressing the CD30 antigen and forms a complex that is internalized within the cell and MMAE is released.
成人常用劑量（仿單摘要）
Classical Hodgkin Lymphoma: 1.2 mg/kg IV q2Weeks (in combination with AVD); not to exceed 120 mg/dose, Continue until a maximum of 12 doses, disease progression, or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe Antibody-drug conjugate (cytotoxic MMAE): can cause fetal harm. Avoid in pregnancy. Women: effective contraception during treatment and for 2 months after; men with female partners: 4 months.
- 哺乳
- Unsafe No human milk data. Avoid breastfeeding during treatment because of possible serious infant harm (low blood counts, nerve or gut toxicity).
已通報的副作用
- Vomiting
- Diarrhea
- Constipation
- Anemia
- Neutropenia
- Pyrexia
哪些人需要特別留意
- Closely monitor for emergence of bacterial, fungal or viral infections
- Acute pancreatitis, including fatal outcomes, reported
- Patients with rapidly proliferating tumor and high tumor burden are at risk of tumor lysis syndrome; closely monitor and treat appropriately
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (72)
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
- Brentuximab + Ritonavir Major
- Brentuximab + Siponimod Major
- Apalutamide + Brentuximab Moderate
- Atazanavir + Brentuximab Moderate
同類別的其他藥品
常見問題
What is Brentuximab used for?
Brentuximab is a medicine in the class oncology. It is used for Hodgkin lymphoma, Lymphoma.
What side effects have been reported with Brentuximab?
Vomiting, Diarrhea, Constipation, Anemia, Neutropenia, Pyrexia.
Can Brentuximab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Antibody-drug conjugate (cytotoxic MMAE): can cause fetal harm. Avoid in pregnancy. Women: effective contraception during treatment and for 2 months after; men with female partners: 4 months. Breastfeeding: Unsafe. No human milk data. Avoid breastfeeding during treatment because of possible serious infant harm (low blood counts, nerve or gut toxicity).
What does Brentuximab interact with?
MediHelp lists 72 known interactions for Brentuximab. Contraindicated: 1 · Major: 7 · Moderate: 47 · Minor: 17. The most serious include Bleomycin, Dengue vaccine, Etrasimod.
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