藥物交互作用
Brexucabtagene autoleucel + Dacarbazine
嚴重程度: 嚴重
Brexucabtagene autoleucel and Dacarbazine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Dacarbazine is a myelosuppressive agent. Given around the time of CAR T-cell therapy it may impair T-cell collection, expansion and persistence and adds to cytopenias and infection risk.
用白話說明這項交互作用的意義
Brexucabtagene autoleucel and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexucabtagene autoleucel belongs to Oncology; Dacarbazine belongs to Oncology.
為什麼會發生
Additive immunosuppression and myelosuppression, with possible cytotoxic effects on CAR T cells.
處置方式
Avoid dacarbazine before leukapheresis and after infusion unless part of a planned protocol. Monitor blood counts and infections closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dacarbazine 的其他交互作用
Brexucabtagene autoleucel 的其他交互作用
常見問題
Can I take Brexucabtagene autoleucel with Dacarbazine?
MediHelp rates the interaction as major. Brexucabtagene autoleucel and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacarbazine is a myelosuppressive agent. Given around the time of CAR T-cell therapy it may impair T-cell collection, expansion and persistence and adds to cytopenias and infection risk.
How serious is the interaction between Brexucabtagene autoleucel and Dacarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dacarbazine before leukapheresis and after infusion unless part of a planned protocol. Monitor blood counts and infections closely.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
