藥物交互作用
Carmustine + Dacarbazine
嚴重程度: 嚴重
Carmustine and Dacarbazine: major interaction.
最後更新
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摘要
Both drugs are cytotoxic alkylating agents that suppress the bone marrow. Combining them can deepen and prolong neutropenia and thrombocytopenia, with delayed nadirs seen with carmustine.
用白話說明這項交互作用的意義
Carmustine and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carmustine belongs to Oncology; Dacarbazine belongs to Oncology.
為什麼會發生
Additive myelosuppression from DNA-damaging alkylating agents.
處置方式
Monitor blood counts weekly or more often for several weeks after treatment, and adjust doses or delay cycles for cytopenias. Support with growth factors or transfusions as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dacarbazine 的其他交互作用
Carmustine 的其他交互作用
常見問題
Can I take Carmustine with Dacarbazine?
MediHelp rates the interaction as major. Carmustine and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are cytotoxic alkylating agents that suppress the bone marrow. Combining them can deepen and prolong neutropenia and thrombocytopenia, with delayed nadirs seen with carmustine.
How serious is the interaction between Carmustine and Dacarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts weekly or more often for several weeks after treatment, and adjust doses or delay cycles for cytopenias. Support with growth factors or transfusions as needed.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
