藥物交互作用
Bumetanide + Tobramycin
嚴重程度: 嚴重
Bumetanide and Tobramycin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Bumetanide with tobramycin increases the risk of cochlear and vestibular damage and of kidney injury. Hearing loss may be irreversible.
用白話說明這項交互作用的意義
Bumetanide and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Tobramycin belongs to Anti Bacterial.
為什麼會發生
Additive ototoxicity and nephrotoxicity, with diuretic-induced volume depletion raising aminoglycoside exposure.
處置方式
Avoid if possible; otherwise correct volume depletion, use the lowest effective doses, and monitor renal function, tobramycin levels and hearing.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tobramycin 的其他交互作用
Bumetanide 的其他交互作用
常見問題
Can I take Bumetanide with Tobramycin?
MediHelp rates the interaction as major. Bumetanide and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bumetanide with tobramycin increases the risk of cochlear and vestibular damage and of kidney injury. Hearing loss may be irreversible.
How serious is the interaction between Bumetanide and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise correct volume depletion, use the lowest effective doses, and monitor renal function, tobramycin levels and hearing.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
