藥物交互作用

Buspirone + Phenelzine

嚴重程度: 禁忌併用

Buspirone and Phenelzine: contraindicated interaction.

最後更新 18 十月 2026 來源: US FDA label

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本頁的臨床內容僅提供英文版。

摘要

Buspirone with a nonselective MAOI such as phenelzine has been associated with hypertensive reactions and risk of serotonin syndrome. Buspirone labeling contraindicates its use with MAOIs. The reaction can be severe and may need hospital care.

用白話說明這項交互作用的意義

Buspirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Buspirone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

證據等級: High

為什麼會發生

Phenelzine inhibits MAO, raising monoamine levels, while buspirone is a serotonergic 5-HT1A partial agonist, so serotonergic toxicity may result; the hypertensive mechanism is not fully established.

處置方式

Do not use together. Allow at least 14 days after stopping phenelzine before starting buspirone, and about a week after stopping buspirone before starting an MAOI.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Buspirone 與 Phenelzine 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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參考資料

Buspirone Hydrochloride Tablets Prescribing Information - Contraindications — FDA Label
Nardil (phenelzine) Prescribing Information - Contraindications and Drug Interactions — FDA Label

常見問題

Can I take Buspirone with Phenelzine?

MediHelp rates the interaction as contraindicated. Buspirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Buspirone with a nonselective MAOI such as phenelzine has been associated with hypertensive reactions and risk of serotonin syndrome. Buspirone labeling contraindicates its use with MAOIs. The reaction can be severe and may need hospital care.

How serious is the interaction between Buspirone and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow at least 14 days after stopping phenelzine before starting buspirone, and about a week after stopping buspirone before starting an MAOI.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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摘要