藥物交互作用
Buspirone + Selegiline transdermal
嚴重程度: 禁忌併用
Buspirone and Selegiline transdermal: contraindicated interaction.
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摘要
Buspirone given with a monoamine oxidase inhibitor has been associated with marked elevations in blood pressure. Selegiline at antidepressant transdermal doses inhibits both MAO isoenzymes, so the risk is relevant and buspirone labeling prohibits MAOI use.
用白話說明這項交互作用的意義
Buspirone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
MAO inhibition combined with buspirone's serotonergic and dopaminergic activity produces a pharmacodynamic effect leading to hypertensive reactions; the exact mechanism is not fully established.
處置方式
Avoid concurrent use; allow a washout of at least 2 weeks after stopping an MAOI before starting buspirone, and the reverse for selegiline.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Buspirone 的其他交互作用
常見問題
Can I take Buspirone with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Buspirone and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Buspirone given with a monoamine oxidase inhibitor has been associated with marked elevations in blood pressure. Selegiline at antidepressant transdermal doses inhibits both MAO isoenzymes, so the risk is relevant and buspirone labeling prohibits MAOI use.
How serious is the interaction between Buspirone and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; allow a washout of at least 2 weeks after stopping an MAOI before starting buspirone, and the reverse for selegiline.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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