藥物交互作用
Cabotegravir + Oxcarbazepine
嚴重程度: 禁忌併用
Cabotegravir and Oxcarbazepine: contraindicated interaction.
最後更新
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摘要
Oxcarbazepine may significantly lower cabotegravir concentrations, particularly with long-acting injectable therapy. This can cause loss of viral suppression and integrase resistance.
用白話說明這項交互作用的意義
Cabotegravir and Oxcarbazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cabotegravir belongs to Anti Virals; Oxcarbazepine belongs to Central Nervous System.
為什麼會發生
Oxcarbazepine induces UGT1A1 (and possibly UGT1A9), increasing cabotegravir glucuronidation.
處置方式
Do not coadminister; use a non-inducing antiseizure drug such as levetiracetam if possible. Otherwise select a different antiretroviral regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cabotegravir 的其他交互作用
Oxcarbazepine 的其他交互作用
常見問題
Can I take Cabotegravir with Oxcarbazepine?
MediHelp rates the interaction as contraindicated. Cabotegravir and Oxcarbazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxcarbazepine may significantly lower cabotegravir concentrations, particularly with long-acting injectable therapy. This can cause loss of viral suppression and integrase resistance.
How serious is the interaction between Cabotegravir and Oxcarbazepine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-inducing antiseizure drug such as levetiracetam if possible. Otherwise select a different antiretroviral regimen.
What other medicines interact with Cabotegravir?
MediHelp also lists interactions of Cabotegravir with, for example, Apalutamide, Carbamazepine, Phenobarbitone. The full list is on the Cabotegravir page.
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