藥物交互作用
Cabotegravir + Rifampicin
嚴重程度: 禁忌併用
Cabotegravir and Rifampicin: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Rifampicin substantially decreases cabotegravir concentrations, creating a high risk of virologic failure and integrase inhibitor resistance. Labeling prohibits the combination.
用白話說明這項交互作用的意義
Cabotegravir and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cabotegravir belongs to Anti Virals; Rifampicin belongs to Anti Bacterial.
為什麼會發生
Rifampicin strongly induces UGT1A1 (and UGT1A9), increasing cabotegravir clearance.
處置方式
Do not use together. Choose an alternative HIV regimen while rifampicin is required.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cabotegravir 的其他交互作用
Rifampicin 的其他交互作用
常見問題
Can I take Cabotegravir with Rifampicin?
MediHelp rates the interaction as contraindicated. Cabotegravir and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin substantially decreases cabotegravir concentrations, creating a high risk of virologic failure and integrase inhibitor resistance. Labeling prohibits the combination.
How serious is the interaction between Cabotegravir and Rifampicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose an alternative HIV regimen while rifampicin is required.
What other medicines interact with Cabotegravir?
MediHelp also lists interactions of Cabotegravir with, for example, Apalutamide, Carbamazepine, Oxcarbazepine. The full list is on the Cabotegravir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
