藥物交互作用
Bosutinib + Oxcarbazepine
嚴重程度: 嚴重
Bosutinib and Oxcarbazepine: major interaction.
最後更新
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摘要
Oxcarbazepine may lower bosutinib exposure and reduce antileukemic efficacy. Strong inducers lower exposure dramatically; oxcarbazepine's effect is likely smaller but still relevant.
用白話說明這項交互作用的意義
Bosutinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
為什麼會發生
CYP3A4 induction by oxcarbazepine increases bosutinib metabolism.
處置方式
Use a non-inducing anticonvulsant where possible. If coadministered, monitor hematologic and molecular response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Oxcarbazepine 的其他交互作用
Bosutinib 的其他交互作用
常見問題
Can I take Bosutinib with Oxcarbazepine?
MediHelp rates the interaction as major. Bosutinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine may lower bosutinib exposure and reduce antileukemic efficacy. Strong inducers lower exposure dramatically; oxcarbazepine's effect is likely smaller but still relevant.
How serious is the interaction between Bosutinib and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant where possible. If coadministered, monitor hematologic and molecular response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
