藥物交互作用
Carbamazepine + Selumetinib
嚴重程度: 嚴重
Carbamazepine and Selumetinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Carbamazepine may lower selumetinib exposure, potentially reducing control of plexiform neurofibromas. Selumetinib is cleared largely by CYP3A4.
用白話說明這項交互作用的意義
Carbamazepine and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Selumetinib belongs to Oncology.
為什麼會發生
Carbamazepine induces CYP3A4, increasing selumetinib metabolism.
處置方式
Avoid strong or moderate CYP3A4 inducers with selumetinib and choose an alternative anticonvulsant. If unavoidable, monitor for loss of response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbamazepine 的其他交互作用
Selumetinib 的其他交互作用
常見問題
Can I take Carbamazepine with Selumetinib?
MediHelp rates the interaction as major. Carbamazepine and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine may lower selumetinib exposure, potentially reducing control of plexiform neurofibromas. Selumetinib is cleared largely by CYP3A4.
How serious is the interaction between Carbamazepine and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong or moderate CYP3A4 inducers with selumetinib and choose an alternative anticonvulsant. If unavoidable, monitor for loss of response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
