藥物交互作用
Cefazolin + Kanamycin
嚴重程度: 中度
Cefazolin and Kanamycin: moderate interaction.
最後更新
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摘要
Cefazolin given with an aminoglycoside such as kanamycin has been associated with a possible additive risk of kidney injury, and aminoglycosides also carry ototoxic risk. Kanamycin is itself markedly nephrotoxic and ototoxic, so any added renal impairment raises aminoglycoside exposure and toxicity.
用白話說明這項交互作用的意義
Cefazolin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive nephrotoxic potential, with reduced renal clearance of the aminoglycoside if kidney function declines.
處置方式
Monitor serum creatinine and urine output and aminoglycoside levels where applicable during combined use. Adjust the kanamycin dose to renal function and watch for hearing or vestibular symptoms.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefazolin 的其他交互作用
常見問題
Can I take Cefazolin with Kanamycin?
MediHelp rates the interaction as moderate. Cefazolin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefazolin given with an aminoglycoside such as kanamycin has been associated with a possible additive risk of kidney injury, and aminoglycosides also carry ototoxic risk. Kanamycin is itself markedly nephrotoxic and ototoxic, so any added renal impairment raises aminoglycoside exposure and toxicity.
How serious is the interaction between Cefazolin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output and aminoglycoside levels where applicable during combined use. Adjust the kanamycin dose to renal function and watch for hearing or vestibular symptoms.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
