藥物交互作用
Cefazolin + Gentamicin
嚴重程度: 中度
Cefazolin and Gentamicin: moderate interaction.
最後更新
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摘要
Giving cefazolin with gentamicin may raise the risk of kidney injury, mainly in patients who are elderly, volume-depleted or have existing renal impairment. The aminoglycoside is the principal nephrotoxic and ototoxic agent, and the combination is often used deliberately, for example in endocarditis.
用白話說明這項交互作用的意義
Cefazolin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefazolin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
為什麼會發生
Additive nephrotoxic potential; cephalosporins may modestly add to aminoglycoside tubular injury.
處置方式
Monitor serum creatinine and gentamicin levels, keep the patient well hydrated and limit the duration of aminoglycoside therapy. Adjust the doses for renal function.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefazolin 的其他交互作用
Gentamicin 的其他交互作用
常見問題
Can I take Cefazolin with Gentamicin?
MediHelp rates the interaction as moderate. Cefazolin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving cefazolin with gentamicin may raise the risk of kidney injury, mainly in patients who are elderly, volume-depleted or have existing renal impairment. The aminoglycoside is the principal nephrotoxic and ototoxic agent, and the combination is often used deliberately, for example in endocarditis.
How serious is the interaction between Cefazolin and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, keep the patient well hydrated and limit the duration of aminoglycoside therapy. Adjust the doses for renal function.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
