藥物交互作用
Cefepime + Sodium picosulfate / magnesium oxide / anhydrous citric acid
嚴重程度: 中度
Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
最後更新
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摘要
Sodium picosulfate is a prodrug activated by colonic bacteria to its laxative form. Antibiotics that suppress colonic flora may reduce this activation and lead to a poorer bowel cleansing before colonoscopy. Systemically given cefepime has less gut effect than oral antibiotics, but labeling still cautions about antibiotics.
用白話說明這項交互作用的意義
Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Antibiotic suppression of colonic bacteria needed to convert sodium picosulfate to its active metabolite.
處置方式
Where possible, avoid starting antibiotics shortly before the bowel prep, or confirm adequate cleansing and consider an alternative preparation if the antibiotic cannot be avoided.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefepime 的其他交互作用
常見問題
Can I take Cefepime with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug activated by colonic bacteria to its laxative form. Antibiotics that suppress colonic flora may reduce this activation and lead to a poorer bowel cleansing before colonoscopy. Systemically given cefepime has less gut effect than oral antibiotics, but labeling still cautions about antibiotics.
How serious is the interaction between Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid starting antibiotics shortly before the bowel prep, or confirm adequate cleansing and consider an alternative preparation if the antibiotic cannot be avoided.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
