藥物交互作用
Cefepime + Gentamicin
嚴重程度: 中度
Cefepime and Gentamicin: moderate interaction.
最後更新
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摘要
Both are given intravenously and both are cleared by the kidney, and gentamicin also carries ototoxicity risk. Cefepime is not strongly nephrotoxic, but renal decline raises exposure to both drugs, increasing gentamicin toxicity and cefepime neurotoxicity.
用白話說明這項交互作用的意義
Cefepime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
為什麼會發生
Possible additive renal effects; both drugs are renally cleared, so declining renal function raises exposure to each.
處置方式
Monitor serum creatinine and gentamicin levels, and adjust the doses of both drugs to renal function. Watch for confusion or myoclonus from cefepime accumulation and for hearing changes.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefepime 的其他交互作用
Gentamicin 的其他交互作用
常見問題
Can I take Cefepime with Gentamicin?
MediHelp rates the interaction as moderate. Cefepime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are given intravenously and both are cleared by the kidney, and gentamicin also carries ototoxicity risk. Cefepime is not strongly nephrotoxic, but renal decline raises exposure to both drugs, increasing gentamicin toxicity and cefepime neurotoxicity.
How serious is the interaction between Cefepime and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, and adjust the doses of both drugs to renal function. Watch for confusion or myoclonus from cefepime accumulation and for hearing changes.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
