藥物交互作用
Cefixime + Plazomicin
嚴重程度: 中度
Cefixime and Plazomicin: moderate interaction.
最後更新
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摘要
Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.
用白話說明這項交互作用的意義
Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefixime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
為什麼會發生
Possible additive nephrotoxicity, with reduced renal clearance of both drugs if kidney function falls.
處置方式
Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefixime 的其他交互作用
Plazomicin 的其他交互作用
常見問題
Can I take Cefixime with Plazomicin?
MediHelp rates the interaction as moderate. Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.
How serious is the interaction between Cefixime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
