藥物交互作用
Cefotetan + Warfarin
嚴重程度: 嚴重
Cefotetan and Warfarin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cefotetan has been associated with hypoprothrombinemia and bleeding, which can add to the effect of warfarin and markedly raise the INR.
用白話說明這項交互作用的意義
Cefotetan and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cefotetan belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
為什麼會發生
Its N-methylthiotetrazole side chain inhibits vitamin K epoxide reductase and gut flora reduce vitamin K availability, adding to warfarin effect.
處置方式
Monitor INR closely during therapy and consider vitamin K supplementation or an alternative antibiotic if INR rises. Reduce warfarin dose as indicated.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Warfarin 的其他交互作用
Cefotetan 的其他交互作用
常見問題
Can I take Cefotetan with Warfarin?
MediHelp rates the interaction as major. Cefotetan and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cefotetan has been associated with hypoprothrombinemia and bleeding, which can add to the effect of warfarin and markedly raise the INR.
How serious is the interaction between Cefotetan and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely during therapy and consider vitamin K supplementation or an alternative antibiotic if INR rises. Reduce warfarin dose as indicated.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
