藥物交互作用
Cefotetan + Dalteparin
嚴重程度: 中度
Cefotetan and Dalteparin: moderate interaction.
最後更新
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摘要
Cefotetan can cause hypoprothrombinemia and platelet dysfunction, which may add to the anticoagulant effect of dalteparin. Bleeding risk is greater with poor nutrition, prolonged therapy or renal impairment.
用白話說明這項交互作用的意義
Cefotetan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Dalteparin belongs to Cardiovascular.
為什麼會發生
Additive hemostatic effects: the N-methylthiotetrazole side chain of cefotetan interferes with vitamin K-dependent clotting factor synthesis and platelet function.
處置方式
Monitor for bleeding and check PT/INR and platelet count in prolonged courses; give vitamin K if coagulopathy develops or choose an alternative antibiotic.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dalteparin 的其他交互作用
Cefotetan 的其他交互作用
常見問題
Can I take Cefotetan with Dalteparin?
MediHelp rates the interaction as moderate. Cefotetan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefotetan can cause hypoprothrombinemia and platelet dysfunction, which may add to the anticoagulant effect of dalteparin. Bleeding risk is greater with poor nutrition, prolonged therapy or renal impairment.
How serious is the interaction between Cefotetan and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check PT/INR and platelet count in prolonged courses; give vitamin K if coagulopathy develops or choose an alternative antibiotic.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
