藥物交互作用

Cefotetan + Fondaparinux

嚴重程度: 中度

Cefotetan and Fondaparinux: moderate interaction.

最後更新 13 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Cefotetan contains an N-methylthiotetrazole side chain that can lower vitamin K-dependent clotting factors and cause bleeding. Combined with fondaparinux, the bleeding risk may rise.

用白話說明這項交互作用的意義

Cefotetan and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefotetan belongs to Anti Bacterial; Fondaparinux belongs to Cardiovascular.

證據等級: Low

為什麼會發生

Additive bleeding tendency from vitamin K antagonism and factor Xa inhibition.

處置方式

Monitor for bleeding signs and INR/prothrombin time, particularly in malnourished or prolonged-therapy patients. Give vitamin K if coagulopathy develops.

可向藥師詢問的問題

Should I take them at different times of day?
Does the dose of either medicine need to change?
Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Cefotetan 與 Fondaparinux 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Cefotetan with Fondaparinux?

MediHelp rates the interaction as moderate. Cefotetan and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefotetan contains an N-methylthiotetrazole side chain that can lower vitamin K-dependent clotting factors and cause bleeding. Combined with fondaparinux, the bleeding risk may rise.

How serious is the interaction between Cefotetan and Fondaparinux?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and INR/prothrombin time, particularly in malnourished or prolonged-therapy patients. Give vitamin K if coagulopathy develops.

What other medicines interact with Fondaparinux?

MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.

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摘要