藥物交互作用
Probenecid + Roxadustat
嚴重程度: 嚴重
Probenecid and Roxadustat: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Probenecid markedly increases roxadustat exposure. This may lead to an excessive rise in haemoglobin and a higher risk of roxadustat-related adverse effects.
用白話說明這項交互作用的意義
Probenecid and Roxadustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Probenecid belongs to Genitourinary; Roxadustat belongs to Miscellaneous.
為什麼會發生
Probenecid inhibits UGT1A9 glucuronidation and renal/hepatic transporters involved in roxadustat elimination.
處置方式
Monitor haemoglobin frequently and reduce the roxadustat dose according to response. Avoid the combination where an alternative exists.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Roxadustat 的其他交互作用
Probenecid 的其他交互作用
常見問題
Can I take Probenecid with Roxadustat?
MediHelp rates the interaction as major. Probenecid and Roxadustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid markedly increases roxadustat exposure. This may lead to an excessive rise in haemoglobin and a higher risk of roxadustat-related adverse effects.
How serious is the interaction between Probenecid and Roxadustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor haemoglobin frequently and reduce the roxadustat dose according to response. Avoid the combination where an alternative exists.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Atorvastatin, Calcium acetate. The full list is on the Roxadustat page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
