藥物交互作用
Celecoxib + Ketorolac intranasal
嚴重程度: 禁忌併用
Celecoxib and Ketorolac intranasal: contraindicated interaction.
最後更新
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摘要
Celecoxib with intranasal ketorolac duplicates NSAID therapy; although celecoxib is COX-2 selective, the combination still adds renal and cardiovascular risk and the ketorolac gastrointestinal and bleeding risk remains. Ketorolac labeling prohibits concomitant NSAIDs.
用白話說明這項交互作用的意義
Celecoxib and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive cyclooxygenase inhibition producing additive renal, cardiovascular and gastrointestinal toxicity.
處置方式
Avoid the combination; use only one NSAID. Use a non-NSAID analgesic for added effect.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Celecoxib 的其他交互作用
常見問題
Can I take Celecoxib with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Celecoxib and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Celecoxib with intranasal ketorolac duplicates NSAID therapy; although celecoxib is COX-2 selective, the combination still adds renal and cardiovascular risk and the ketorolac gastrointestinal and bleeding risk remains. Ketorolac labeling prohibits concomitant NSAIDs.
How serious is the interaction between Celecoxib and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use only one NSAID. Use a non-NSAID analgesic for added effect.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Celecoxib page.
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