藥物交互作用
Apixaban + Celecoxib
嚴重程度: 嚴重
Apixaban and Celecoxib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Celecoxib has less antiplatelet effect than nonselective NSAIDs but can still cause gastrointestinal mucosal injury, and apixaban adds anticoagulation. The combination increases the risk of clinically significant bleeding.
用白話說明這項交互作用的意義
Apixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
為什麼會發生
Additive bleeding risk from NSAID mucosal injury and factor Xa inhibition.
處置方式
Avoid if possible and use paracetamol for pain. If celecoxib is required, give the lowest dose for the shortest time with gastroprotection and monitor for bleeding.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Celecoxib 的其他交互作用
Apixaban 的其他交互作用
常見問題
Can I take Apixaban with Celecoxib?
MediHelp rates the interaction as major. Apixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Celecoxib has less antiplatelet effect than nonselective NSAIDs but can still cause gastrointestinal mucosal injury, and apixaban adds anticoagulation. The combination increases the risk of clinically significant bleeding.
How serious is the interaction between Apixaban and Celecoxib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use paracetamol for pain. If celecoxib is required, give the lowest dose for the shortest time with gastroprotection and monitor for bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
