藥物交互作用
Cenobamate + Lorlatinib
嚴重程度: 嚴重
Cenobamate and Lorlatinib: major interaction.
最後更新
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摘要
Cenobamate induces CYP3A4 and may substantially lower lorlatinib exposure. Strong inducers of this kind can cause loss of lorlatinib efficacy, and lorlatinib itself can raise liver enzymes when exposure is altered or combined with inducers.
用白話說明這項交互作用的意義
Cenobamate and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cenobamate belongs to Central Nervous System; Lorlatinib belongs to Oncology.
為什麼會發生
Cenobamate induces CYP3A4, accelerating lorlatinib clearance.
處置方式
Avoid the combination if an alternative antiseizure drug is possible; otherwise monitor tumor response and liver enzymes closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lorlatinib 的其他交互作用
Cenobamate 的其他交互作用
常見問題
Can I take Cenobamate with Lorlatinib?
MediHelp rates the interaction as major. Cenobamate and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cenobamate induces CYP3A4 and may substantially lower lorlatinib exposure. Strong inducers of this kind can cause loss of lorlatinib efficacy, and lorlatinib itself can raise liver enzymes when exposure is altered or combined with inducers.
How serious is the interaction between Cenobamate and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antiseizure drug is possible; otherwise monitor tumor response and liver enzymes closely.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
