藥物交互作用

Ceritinib + Tolvaptan

嚴重程度: 禁忌併用

Ceritinib and Tolvaptan: contraindicated interaction.

最後更新 13 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Ceritinib is a strong CYP3A4 inhibitor and is expected to increase tolvaptan concentrations substantially. This may lead to excessive aquaresis, volume depletion, and overly rapid sodium rise.

用白話說明這項交互作用的意義

Ceritinib and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ceritinib belongs to Oncology; Tolvaptan belongs to Endocrine.

證據等級: Moderate

為什麼會發生

Inhibition of CYP3A4 reduces tolvaptan metabolism.

處置方式

Avoid concurrent use; consider an alternative to one agent. If co-use is unavoidable, monitor serum sodium and fluid status frequently.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Ceritinib 與 Tolvaptan 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Ceritinib with Tolvaptan?

MediHelp rates the interaction as contraindicated. Ceritinib and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceritinib is a strong CYP3A4 inhibitor and is expected to increase tolvaptan concentrations substantially. This may lead to excessive aquaresis, volume depletion, and overly rapid sodium rise.

How serious is the interaction between Ceritinib and Tolvaptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; consider an alternative to one agent. If co-use is unavoidable, monitor serum sodium and fluid status frequently.

What other medicines interact with Tolvaptan?

MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Cobicistat, Conivaptan. The full list is on the Tolvaptan page.

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摘要