藥物交互作用

Darunavir + Tolvaptan

嚴重程度: 禁忌併用

Darunavir and Tolvaptan: contraindicated interaction.

最後更新 13 十月 2026

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本頁的臨床內容僅提供英文版。

摘要

Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and is expected to increase tolvaptan exposure. This may cause excessive aquaresis, dehydration, and rapid sodium shifts.

用白話說明這項交互作用的意義

Darunavir and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Darunavir belongs to Anti Virals; Tolvaptan belongs to Endocrine.

證據等級: Moderate

為什麼會發生

CYP3A4 inhibition, boosted by ritonavir or cobicistat, reduces tolvaptan metabolism.

處置方式

Avoid the combination; consider alternatives. If needed, monitor serum sodium and volume status closely.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Darunavir 與 Tolvaptan 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Darunavir with Tolvaptan?

MediHelp rates the interaction as contraindicated. Darunavir and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and is expected to increase tolvaptan exposure. This may cause excessive aquaresis, dehydration, and rapid sodium shifts.

How serious is the interaction between Darunavir and Tolvaptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider alternatives. If needed, monitor serum sodium and volume status closely.

What other medicines interact with Tolvaptan?

MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.

在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查

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摘要