藥品參考
Tolvaptan
Tolvaptan is a medicine in the class endocrine. It is used for hyponatremia.
- 藥物類別: Endocrine
- 用途: hyponatremia
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Endocrine
- ATC 代碼
- C03XA01
- 常見劑型
- 錠劑
- 常見規格
- 30 mg, 15 mg
- 已知交互作用
- 245 (禁忌併用: 19 · 嚴重: 36 · 中度: 99 · 輕微: 91)
- 商品名
- 9
- 國家與市場
- 4
用途
作用方式
Selective vasopressin V2-receptor antagonist that causes an increase in urine water excretion that results in an increase in free water clearance (aquaresis), a decrease in urine osmolality, and a resulting increase in serum sodium concentration
成人常用劑量（仿單摘要）
Hyponatremia Initial: 15 mg PO qDay, Maintenance: May increase to 30 mg qDay after at least 24 hr to achieve the optimal serum sodium level; not to exceed 60 mg/day, Not to exceed 30 days of treatment
懷孕與哺乳
- 懷孕
- Unsafe The use of this drug is not recommended during pregnancy. Some authorities consider it contraindicated.
- 哺乳
- Unsafe Use is not recommended, and some authorities consider it contraindicated.
已通報的副作用
- Dry mouth
- Nausea
- Thirst
- Pollakiuria
- Urinary frequency/output increased
哪些人需要特別留意
- Measure ALT, AST and bilirubin before initiating treatment, at 2 weeks and 4 weeks after initiation, monthly for the first 18 months ,and q3Months thereafter
- Concomitant use of strong CYP3A inhibitors
- Hypernatremia, hypovolemia, and/or dehydration may occur; encourage patient to drink whenever thirsty
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (245)
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
- Indinavir + Tolvaptan Contraindicated
- Itraconazole + Tolvaptan Contraindicated
- Ketoconazole + Tolvaptan Contraindicated
- Levoketoconazole + Tolvaptan Contraindicated
同類別的其他藥品
常見問題
What is Tolvaptan used for?
Tolvaptan is a medicine in the class endocrine. It is used for Hyponatremia, Polycystic kidney disease.
What side effects have been reported with Tolvaptan?
Dry mouth, Nausea, Thirst, Pollakiuria, Urinary frequency/output increased.
Can Tolvaptan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. The use of this drug is not recommended during pregnancy. Some authorities consider it contraindicated. Breastfeeding: Unsafe. Use is not recommended, and some authorities consider it contraindicated.
What does Tolvaptan interact with?
MediHelp lists 245 known interactions for Tolvaptan. Contraindicated: 19 · Major: 36 · Moderate: 99 · Minor: 91. The most serious include Atazanavir, Ceritinib, Cobicistat.
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