藥物交互作用
Ceritinib + Eletriptan
嚴重程度: 禁忌併用
Ceritinib and Eletriptan: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Ceritinib is a strong CYP3A4 inhibitor and may considerably raise eletriptan exposure. Elevated eletriptan levels increase the likelihood of vasospastic and hypertensive adverse effects.
用白話說明這項交互作用的意義
Ceritinib and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ceritinib belongs to Oncology; Eletriptan belongs to Central Nervous System.
為什麼會發生
Ceritinib inhibits CYP3A4, reducing first-pass and systemic clearance of eletriptan.
處置方式
Avoid eletriptan during ceritinib therapy and for 72 hours after a strong CYP3A4 inhibitor. Use a triptan not metabolized mainly by CYP3A4.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eletriptan 的其他交互作用
Ceritinib 的其他交互作用
常見問題
Can I take Ceritinib with Eletriptan?
MediHelp rates the interaction as contraindicated. Ceritinib and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceritinib is a strong CYP3A4 inhibitor and may considerably raise eletriptan exposure. Elevated eletriptan levels increase the likelihood of vasospastic and hypertensive adverse effects.
How serious is the interaction between Ceritinib and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during ceritinib therapy and for 72 hours after a strong CYP3A4 inhibitor. Use a triptan not metabolized mainly by CYP3A4.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Eletriptan page.
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